Within TIBCO Spotfire Analyst client, users can enable Natural string sorting for string-type data columns. However, TIBCO does not expose the same mechanism for use within IronPython or .NET.
Please enable access to the NaturalStringComparer that Spotfire uses. With would allow something like the following within an IronPython script:
from Spotfire.Dxp.Data.Something import NaturalStringComparer
column = table.Columns[columnName]
column.Properties.Comparer = NaturalStringComparer()